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DMSO for "super absorption" of Decarboxylated Cannabis Oil (video)

DMSO Rub Recipe DMSO/Cannabis Cure Cannabis Pain Rub DMSO cannabis oil Transdermal cannabis Cannabis dermal absorption DMSO organic sulfur DMSO marijuana oil DMSO Magnesium chloride pain

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#1 SkunkyAroma

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Posted 18 December 2015 - 06:28 AM



#2 SkunkyAroma

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Posted 20 December 2015 - 04:48 AM

Cannabis Oil, Magnesium and DMSO Rub


Both Magnesium and DMSO have pain relieving properties plus DMSO acts as an anti-inflammatory. Adding decarboxylized cannabis oil to the rub makes it amazing.

The recipe is pretty simple and makes about 1 cup of finished rub





¼ cup cannabis-infused organic coconut oil

¼ cup saturated magnesium chloride solution

¼ cup 99% DMSO (use a metal measuring cup with the DMSO)

1 tablespoon of avocado oil



I make the saturated magnesium chloride by adding distilled water to a jar filled about ¾ of the way with magnesium chloride flakes. Allow to sit for about an hour before use so that as much magnesium chloride as possible is dissolved. There should always be some solid magnesium chloride left on the bottom so you know that you have a saturated solution

Place the coconut cannabis oil in at least a 16 oz wide mouth jar (this avoids it going everywhere as you whip it) and place in the microwave on low until it is mostly melted. Remove from the microwave and allow it to sit until any remaining lumps have melted. This avoids getting the coconut cannabis oil any hotter then necessary and will allow the rub to set up faster.

Melted Coconut Cannabis Oil

Add the DMSO, avocado oil and saturated magnesium chloride solution to the coconut cannabis oil, place the jar in a bowl of ice and water and start to whip it. I use a mini-whisk that I took the handle off of in an electric drill but you could also use a mixer.

Rub in Ice Bath Whisk

Whip the mixture until you start to see what sort of looks like milk curds starting to form. The mixture should hold its shape at this point like soft serve ice cream. If you whip too long the mixture will start to separate again. If this does happen just warm it up and whip it again.

Finished DMSO Rub

Place the finished rub in a glass jar (DMSO dissolves some plastics) and keep in a cool (not cold) place to store.

Apply to any sore joint or muscle and rub in well, you should start to feel relief in about 10 minutes. Avoid any open wounds as the magnesium will burn just like if you got salt in the wound.

#3 SkunkyAroma

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Posted 25 December 2015 - 05:23 AM

If there is two miracle products on the planet that can virtually help assisting in you curing virtually every disease it is DMSO and HYDROGEN PEROXIDE.

 

The reason you have never heard about these two products is because they are 100 percent unpatentable, and they are incredibly inexpensive. This means that no one will spend any serious money reviewing the effects of these products, and the pharmaceutical industry categorically wants these products to be off the market and the information about them suppressed. These are miracle products. These products help cure herpes, cancer, arthritis, MS, muscular dystrophy, and virtually all virus type disease and degenerative diseases. There are volumes that can be written about these two products. What these two products effectively do is get oxygen into your body. Nobel Prize winning author DR. Otto Wallberg discovered that cancer and all viruses cannot live in an oxygen rich environment. When your body Ph is acidic, there is very little oxygen in your blood and in your tissues. When you flood your body with oxygen, your body Ph goes from acidic to alkaline. When your body is flooded with oxygen, viruses instantly die, and your energy levels skyrockets. Using DMSO topically can rid a person of all types of diseases that are viral based, from herpes, perrones disease, shingles, warts, moles, etc. Hydrogen peroxide can be used topically and, also taken orally to flood your body with oxygen. It can also be taken intravenously, and is used in medical clinics around the world that specialize in cancer. One particular hospital in Mexico has virtually a 100 percent success rate in eliminating cancer in just a matter of weeks by giving intravenous ozone and hydrogen peroxide. I encourage you to go to the internet and type in DMSO and start reading about its powerful effects. Also, type in hydrogen peroxide and start reading about how it is used to cure and prevent all types of diseases. Please know that most of the information is being suppressed and the pharmaceutical industry has set up a host of front web sites talking negatively about these two products. I can assure you that all the negative discussion is misleading and untrue. These are miracle products. They can help you cure and prevent cancer and virtually all types of medical diseases. They must be used correctly, and I advise you to use them under the supervision of a licensed alternative healthcare practitioner.

 

THIS INFORMATION HERE IS DESIGNED TO HELP YOU MAKE INFORMED DECISIONS ABOUT YOUR LIFE AND HEALTH. IT IS NOT INTENDED AS A SUBSTITUTE FOR ANY TREATMENT THAT MAY HAVE BEEN PRESCRIBED BY YOUR DOCTOR. IF YOU SUSPECT THAT YOU HAVE A MEDICAL PROBLEM, WE URGE YOU TO SEEK COMPETENT MEDICAL HELP.



#4 SkunkyAroma

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Posted 11 January 2016 - 05:45 PM

Another Rub Recipe:

 

 

 

Topical Ointment

This makes an excellent topical ointment. Amazing results for joint pain, after surgery, arthritis, any pain on body, it works amazingly fast. The castor oil and DMSO brings it deep inside. This is just what we are doing and you need to check it with your doctor before using it. Below is the recipe

1 part coconut oil
1 part castor oil
1 part DMSO
Mix well then add cannabis oil (we are using 5 to 10 grams per pint of mixture)
We also add drops of mint oil to make it smell good (experiment with your favorite essential oil)
Also other herbs might be beneficial for specific conditions like Arnica (always do your own research)



#5 SkunkyAroma

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Posted 17 May 2016 - 11:13 PM

I’ve always been interested in how these skin patches work, specifically what they contain that transfers the enclosed drugs into the skin. After a quick search I found that one common ingredient in many transdermal patches is the chemical DMSO (if you are in a lab, you may have heard of it). DMSO (dimethyl sulfoxide) is a solvent and a by-product of the wood industry. In 1961 a Dr. Jacob noted that the chemical was able to penetrate the skin deeply without causing any damage. Later it was observed to be a superior solvent for pharmaceuticals, and capable of transporting chemicals across and into skin (for better or worse). Obviously you’d want to be careful with DMSO (for example, LSD is sometimes dissolved in DMSO), but these properties made it quite useful for introducing therapeutic drugs into the skin via the patch. The release of drug was constant and predictable, and patches were difficult to abuse (the strong painkiller fentanyl is sometimes delivered this way.)

 

Dimethyl sulfoxide (DMSO), a by-product of the wood industry, has been in use as a commercial solvent since 1953. It is also one of the most studied but least understood pharmaceutical agents of our time--at least in the United States. According to Stanley Jacob, MD, a former head of the organ transplant program at Oregon Health Sciences University in Portland, more than 40,000 articles on its chemistry have appeared in scientific journals, which, in conjunction with thousands of laboratory studies, provide strong evidence of a wide variety of properties. (See Major Properties Attributed to DMSO) Worldwide, some 11,000 articles have been written on its medical and clinical implications, and in 125 countries throughout the world, including Canada, Great Britain, Germany, and Japan, doctors prescribe it for a variety of ailments, including pain, inflammation, scleroderma, interstitial cystitis, and arthritis elevated intercranial pressure.

Yet in the United States, DMSO has Food and Drug Administration (FDA) approval only for use as a preservative of organs for transplant and for interstitial cystitis, a bladder disease. It has fallen out of the limelight and out of the mainstream of medical discourse, leading some to believe that it was discredited. The truth is more complicated.

DMSO: A History of Controversy

The history of DMSO as a pharmaceutical began in 1961, when Dr. Jacob was head of the organ transplant program at Oregon Health Sciences University. It all started when he first picked up a bottle of the colorless liquid. While investigating its potential as a preservative for organs, he quickly discovered that it penetrated the skin quickly and deeply without damaging it. He was intrigued. Thus began his lifelong investigation of the drug.

The news media soon got word of his discovery, and it was not long before reporters, the pharmaceutical industry, and patients with a variety of medical complaints jumped on the news. Because it was available for industrial uses, patients could dose themselves. This early public interest interfered with the ability of Dr. Jacob--or, later, the FDA--to see that experimentation and use were safe and controlled and may have contributed to the souring of the mainstream medical community on it.

Why, if DMSO possesses half the capabilities claimed by Dr. Jacob and others, is it still on the sidelines of medicine in the United States today?

"It's a square peg being pushed into a round hole," says Dr. Jacob. "It doesn't follow the rifle approach of one agent against one disease entity. It's the aspirin of our era. If aspirin were to come along today, it would have the same problem. If someone gave you a little white pill and said take this and your headache will go away, your body temperature will go down, it will help prevent strokes and major heart problems--what would you think?"

Others cite DMSO's principal side effect: an odd odor, akin to that of garlic, that emanates from the mouth shortly after use, even if use is through the skin. Certainly, this odor has made double-blinded studies difficult. Such studies are based on the premise that no one, neither doctor nor patient, knows which patient receives the drug and which the placebo, but this drug announces its presence within minutes.

Others, such as Terry Bristol, a Ph.D. candidate from the University of London and president of the Institute for Science, Engineering and Public Policy in Portland, Oregon, who assisted Dr. Jacob with his research in the 1960s and 1970s, believe that the smell of DMSO may also have put off the drug companies, that feared it would be hard to market. Worse, however, for the pharmaceutical companies was the fact that no company could acquire an exclusive patent for DMSO, a major consideration when the clinical testing required to win FDA approval for a drug routinely runs into millions of dollars. In addition, says Mr. Bristol, DMSO, with its wide range of attributes, would compete with many drugs these companies already have on the market or in development.

The FDA and DMSO

In the first flush of enthusiasm over the drug, six pharmaceutical companies embarked on clinical studies. Then, in November 1965, a woman in Ireland died of an allergic reaction after taking DMSO and several other drugs. Although the precise cause of the woman's death was never determined, the press reported it to be DMSO. Two months later, the FDA closed down clinical trials in the United States, citing the woman's death and changes in the lenses of certain laboratory animals that had been given doses of the drug many times higher than would be given humans.

Some 20 years and hundreds of laboratory and human studies later, no other deaths have been reported, nor have changes in the eyes of humans been documented or claimed. Since then, however, the FDA has refused seven applications to conduct clinical studies, and approved only 1, for intersititial cystitis, which subsequently was approved for prescriptive use in 1978.

Dr. Jacob believes the FDA "blackballed" DMSO, actively trying to kill interest in a drug that could end much suffering. Jack de la Torre, MD, Ph.D., professor of neurosurgery and physiology at the University of New Mexico Medical School in Albuquerque, a pioneer in the use of DMSO and closed head injury, says, "Years ago the FDA had a sort of chip on its shoulder because it thought DMSO was some kind of snake oil medicine. There were people there who were openly biased against the compound even though they knew very little about it. With the new administration at that agency, it has changed a bit." The FDA recently granted permission to conduct clinical trials in Dr. de la Torre's field of closed head injury.

DMSO Penetrates Membranes and Eases Pain

The first quality that struck Dr. Jacob about the drug was its ability to pass through membranes, an ability that has been verified by numerous subsequent researchers.1 DMSO's ability to do this varies proportionally with its strength--up to a 90 percent solution. From 70 percent to 90 percent has been found to be the most effective strength across the skin, and, oddly, performance drops with concentrations higher than 90 percent. Lower concentrations are sufficient to cross other membranes. Thus, 15 percent DMSO will easily penetrate the bladder.2

In addition, DMSO can carry other drugs with it across membranes. It is more successful ferrying some drugs, such as morphine sulfate, penicillin, steroids, and cortisone, than others, such as insulin. What it will carry depends on the molecular weight, shape, and electrochemistry of the molecules. This property would enable DMSO to act as a new drug delivery system that would lower the risk of infection occurring whenever skin is penetrated.

DMSO perhaps has been used most widely as a topical analgesic, in a 70 percent DMSO, 30 percent water solution. Laboratory studies suggest that DMSO cuts pain by blocking peripheral nerve C fibers.3 Several clinical trials have demonstrated its effectiveness,4,5 although in one trial, no benefit was found.6 Burns, cuts, and sprains have been treated with DMSO. Relief is reported to be almost immediate, lasting up to 6 hours. A number of sports teams and Olympic athletes have used DMSO, although some have since moved on to other treatment modalities. When administration ceases, so do the effects of the drug.

Dr. Jacob said at a hearing of the U.S. Senate Subcommittee on Health in 1980, "DMSO is one of the few agents in which effectiveness can be demonstrated before the eyes of the observers....If we have patients appear before the Committee with edematous sprained ankles, the application of DMSO would be followed by objective diminution of swelling within an hour. No other therapeutic modality will do this."

Chronic pain patients often have to apply the substance for 6 weeks before a change occurs, but many report relief to a degree they had not been able to obtain from any other source.

DMSO and Inflammation

DMSO reduces inflammation by several mechanisms. It is an antioxidant, a scavenger of the free radicals that gather at the site of injury. This capability has been observed in experiments with laboratory animals7 and in 150 ulcerative colitis patients in a double-blinded randomized study in Baghdad, Iraq.8 DMSO also stabilizes membranes and slows or stops leakage from injured cells.

At the Cleveland Clinic Foundation in Cleveland, Ohio, in 1978, 213 patients with inflammatory genitourinary disorders were studied. Researchers concluded that DMSO brought significant relief to the majority of patients. They recommended the drug for all inflammatory conditions not caused by infection or tumor in which symptoms were severe or patients failed to respond to conventional therapy.9

Stephen Edelson, MD, F.A.A.F.P., F.A.A.E.M., who practices medicine at the Environmental and Preventive Health Center of Atlanta, has used DMSO extensively for 4 years. "We use it intravenously as well as locally," he says. "We use it for all sorts of inflammatory conditions, from people with rheumatoid arthritis to people with chronic low back inflammatory-type symptoms, silicon immune toxicity syndromes, any kind of autoimmune process.

"DMSO is not a cure," he continues. "It is a symptomatic approach used while you try to figure out why the individual has the process going on. When patients come in with rheumatoid arthritis, we put them on IV DMSO, maybe three times a week, while we are evaluating the causes of the disease, and it is amazing how free they get. It really is a dramatic treatment."

As for side effects, Dr. Edelson says: "Occasionally, a patient will develop a headache from it, when used intravenously--and it is dose related." He continues: "If you give a large dose, [the patient] will get a headache. And we use large doses. I have used as much as 30ÝmlÝIV over a couple of hours. The odor is a problem. Some men have to move out of the room [shared] with their wives and into separate bedrooms. That is basically the only problem."

DMSO was the first nonsteroidal anti-inflammatory discovered since aspirin. Mr. Bristol believes that it was that discovery that spurred pharmaceutical companies on to the development on other varieties of nonsteroidal anti-inflammatories. "Pharmaceutical companies were saying that if DMSO can do this, so can other compounds," says Mr. Bristol. "The shame is that DMSO is less toxic and has less int he way of side effects than any of them."

Collagen and Scleroderma

Scleroderma is a rare, disabling, and sometimes fatal disease, resulting form an abnormal buildup of collagen in the body. The body swells, the skin--particularly on hands and face--becomes dense and leathery, and calcium deposits in joints cause difficulty of movement. Fatigue and difficulty in breathing may ensue. Amputation of affected digits may be necessary. The cause of scleroderma is unknown, and, until DMSO arrived, there was no known effective treatment.

Arthur Scherbel, MD, of the department of rheumatic diseases and pathology at the Cleveland Clinic Foundation, conducted a study using DMSO with 42 scleroderma patients who had already exhausted all other possible therapies without relief. Dr. Scherbel and his coworkers concluded 26 of the 42 showed good or excellent improvement. Histotoxic changes were observed together with healing of ischemic ulcers on fingertips, relief from pain and stiffness, and an increase in strength. The investigators noted, "It should be emphasized that these have never been observed with any other mode of therapy."10 Researchers in other studies have since come to similar conclusions.11

Does DMSO Help Arthritis?

It was inevitable that DMSO, with its pain-relieving, collagen-softening, and anti-inflammatory characteristics, would be employed against arthritis, and its use has been linked to arthritis as much as to any condition. Yet the FDA has never given approval for this indication and has, in fact, turned down three Investigational New Drug (IND) applications to conduct extensive clinical trials.

Moreover, its use for arthritis remains controversial. Robert Bennett, MD, F.R.C.P., F.A.C.R., F.A.C.P., professor of medicine and chief, division of arthritis and rheumatic disease at Oregon Health Sciences University (Dr. Jacob's university), says other drugs work better. Dava Sobel and Arthur Klein conducted their own informal study of 47 arthritis patients using DMSO in preparation for writing their book, Arthritis: What Works, and came to the same conclusion.12

Yet laboratory studies have indicated that DMSO's capacity as a free-radical scavenger suggests an important role for it in arthritis.13 The Committee of Clinical Drug Trials of the Japanese Rheumatism Association conducted a trial with 318 patients at several clinics using 90 percent DMSO and concluded that DMSO relieved joint pain and increased range of joint motion and grip strength, although performing better in more recent cases of the disease.14 It is employed widely in the former Soviet Union for all the different types of arthritis, as it is in other countries around the world.

Dr. Jacob remains convinced that it can play a significant role in the treatment of arthritis. "You talk to veterinarians associated with any race track, and you'll find there's hardly an animal there that hasn't been treated with DMSO. No veterinarian is going to give his patient something that does not work. There's no placebo effect on a horse."

DMSO and Central Nervous System Trauma

Since 1971, Dr. de la Torre, then at the University of Chicago, has experimented using DMSO with injury to the central nervous system. Working with laboratory animals, he discovered that DMSO lowered intracranial pressure faster and more effectively than any other drug. DMSO also stabilized blood pressure, improved respiration, and increased urine output by five times and increased blood flow through the spinal cord to areas of injury.15-17 Since then, DMSO has been employed with human patients suffering severe head trauma, initially those whose intracranial pressure remained high despite the administration of mannitol, steroids, and barbiturates. In humans, as well as animals, it has proven the first drug to significantly lower intracranial pressure, the number one problem with severe head trauma.

"We believe that DMSO may be a very good product for stroke," says Dr. de la Torre, "and that is a devastating illness which affects many more people than head injury. We have done some preliminary clinical trials, and there's a lot of animal data showing that it is a very good agent in dissolving clots."

Other Possible Applications for DMSO

Many other uses for DMSO have been hypothesized from its known qualities hand have been tested in the laboratory or in small clinical trials. Mr. Bristol speaks with frustration about important findings that have never been followed up on because of the difficulty in finding funding and because "to have on your resume these days that you've worked on DMSO is the kiss of death." It is simply too controversial. A sampling of some other possible applications for this drug follows.

DMSO as long been used to promote healing. People who have it on hand often use it for minor cuts and burns and report that recovery is speedy. Several studies have documented DMSO use with soft tissue damage, local tissue death, skin ulcers, and burns.18-21

In relation to cancer, several properties of DMSO have gained attention. In one study with rats, DMSO was found to delay the spread of one cancer and prolong survival rates with another.22 In other studies, it has been found to protect noncancer cells while potentiating the chemotherapeutic agent.

Much has been written recently about the worldwide crisis in antibiotic resistance among bacteria (see Alternative & Complementary Therapies, Volume 2, Number 3, 1996, pages 140-144) Here, too, DMSO may be able to play a role. Researcher as early as 1975 discovered that it could break down the resistance certain bacteria have developed.23

In addition to its ability to lower intracranial pressure following closed head injury, Dr. de la Torre's work suggests that the drug may actually have the ability to prevent paralysis, given its ability to speedily clean out cellular debris and stop the inflammation that prevents blood from reaching muscle, leading to the death of muscle tissue.

With its great antioxidant powers, DMSO could be used to mitigate some of the effects of aging, but little work has been done to investigate this possibility. Toxic shock, radiation sickness, and septicemia have all been postulated as responsive to DMSO, as have other conditions too numerous to mention here.

DMSO in the Future

Will DMSO ever sit on the shelves of pharmacies in this country as a legal prescriptive for many of the conditions it may be able to address? Will the studies we need to discover when this drug is most appropriate ever be done? Given the difficulties the drug has run into so far and the recent development of new drugs that perform some of the same functions, Mr. Bristol is doubtful. Others, however, such as Dr. Jacob and Dr. de la Torre, see the FDA approval of DMSO for interstitial cystitis and the more recent FDA go-ahead for DMSO trials with closed head injury as new indications of hope. The cystitis approval means that physicians may use it at their discretion for other uses, giving DMSO a new legitimacy.

Dr. Jacob continues to believe that DMSO should not even be called a drug but is more correctly a new therapeutic principle, with an effect on medicine that will be profound in many areas. Whether that is true cannot be known without extensive a publicly reported trials, which are dependent on the willingness of researchers to undertake rigorous studies in this still-unfashionable tack and of pharmaceutical companies and other investors to back them up. That this is a live issue is proved by the difficulty the investigators with approval to test DMSO for closed head injury clinically are having finding funds to conduct the trials.

In 1980, testifying before the Select Committee on Agin of the U.S. House of Representatives, Dr. Scherbel said, "The controversy that exists over the clinical effectiveness of DMSO is not well-founded--clinical effectiveness may be variable in different patients. If toxicity is consistently minimal, the drug should not be restricted from practice. The clinical effectiveness of DMSO can be decided with complete satisfaction if the drug is made available to the practicing physician. The number of patient complaints about pain and the number of phone calls to the doctor's office will decide quickly whether or not the drug is effective."

It may be premature to call for the full rehabilitation of DMSO, but it is time to call for a full investigation of its true range of capabilities.



#6 SkunkyAroma

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Posted 17 May 2016 - 11:26 PM

DMSO
By Ben Fuchs
 
 
DMSO

DMSO is the most powerful, effective and safe pain reliever you’ve never heard of. And that’s not all. According to Dr. Morton Walker writing in the book “DMSO, Nature’s Healer”, DMSO can effectively treat skin lesions ulcerations cataracts and reduce the painful symptoms of shingles too. It’s a cancer fighter, an anti-inflammatory and an FDA approved treatment for interstitial cystitis, a painful urinary tract condition. And, it’s been shown to pretty darn effective for treating tinea versicolor, a fungal infection of the skin. According to Lazaro Sehtman, M.D, DMSO was 100 percent effective in eliminating the unpleasant fungus in 42 separate cases.

 

Dimethyl-sulfoxide-DMSO-450.jpg

By Rifleman 82 at en.wikipedia, from Wikimedia Commons

 

But by far the most interesting and unusual property of DMSO is its ability to deliver active material through the typically impermeable skin surface. This property to help “drive” substances through the skin and into the blood and internal milieu of the body is known as transdermal penetration and nothing does it better than non-toxic DMSO.

If you’re interested in using DMSO for its transdermal properties, here’s what you want to do. First, check with the doctor who prescribed your medication before you do this because you’re going to get a rapid effect and because you’re bypassing the liver’s protective effects, if you don’t adjust your dose downward you could end with side effects or toxicity. Also, you may want to check yourself for DMSO sensitivity by applying a small amount to your forearm and checking for rash or irritation.

Once you’ve gotten your doctor on board, mix your medication or whatever chemical you want to experiment with in a little DMSO. Once you’ve gotten your drugs dissolved in a solution, apply a specific amount with a syringe ideally to a cotton ball. Do the math so you know how much medication is in the solution and in the liquid that you’re applying on the cotton ball. That way if you end up with to a large or too small a dose you can correct more effectively. Or if you end up with just the right effects you’ll be able to keep your dose consistent.

After applying the solution the cotton ball, apply it to an area on the body. The thinner skin areas like your forearm or your neck or inner thigh will give you the most rapid absorption. Thicker skin areas like the palm of your hand or the sole of your foot will give you slower absorption. If you really want rapid absorption, you can try exfoliating the area you’re applying your solution to with some apple cider vinegar or lemon or lime juice. Rubbing the solution in will help drive the material through the skin, and if you apply a bandage to the solution after you apply, again you can help accelerate the penetration process (patches always improve penetration). Be extremely careful of contaminating your solution because whatever is combined with the DMSO is going to penetrating just as effectively as your intended medication substance.

If you have an injured area you can try this with aspirin or MSM sulfur. If you live in an area like California or Colorado where marijuana is legal you can mix your DMSO with some pot and that way you won’t have to smoke it or eat it. Bodybuilders have been known to use DMSO with anabolic steroids (only with a doctor’s prescription, of course), some cancer patients have been known to use DMSO solution for their chemotherapy. And DMSO may have anti-cancer benefits on its own. It targets cancer cells and when it’s mixed with chemotherapy it’s likely that the medication will also target malignancies.



#7 SkunkyAroma

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Posted 12 July 2016 - 08:31 PM

  On a late fall day in 1964, Virginia Larson was hit by a speeding car in her hometown of Wheaton, Ill. She spent the next three years in a wheelchair and 17 years in constant, debilitating pain. She was utterly dependent on painkillers, and yet still was in such agony that she cried in her sleep. Her physicians assured her it would only get worse. Then last July 23 she visited the Portland, Oreg. clinic of Dr. Stanley Jacob. There she received injections and topical applications of a controversial drug known as DMSO. Now, at 47, the pain is all but gone. "If the house caught fire," she says, "I'd say, 'Forget the jewelry—just get my DMSO.' "

Jim Courtney, 41, drove a semi for a living until his highway accident in February 1976. It left him in pain so enveloping he toyed with suicide. "You just get so tired of hurting you don't give a damn what happens," he says. "I found myself popping Percodan like it was going out of style. One day I picked up my gun and started playing Russian roulette." He survived, but it wasn't until his first experience with DMSO in January 1979, Courtney says, that he began to live again. "Because of DMSO," he says, "I believe in miracles."

It tastes like a bad oyster, smells like garlic on the breath and leaves the scent of rotten cabbages in the air. A byproduct of wood chips during the manufacture of plain brown paper, it costs a few cents an ounce to produce and it is used full-strength as an industrial solvent. Selling it as a medical treatment (except for one bladder disorder, interstitial cystitis) is illegal in all but three of the 50 states. But DMSO—dimethyl sulfoxide—is attracting increasing numbers of believers among the millions of Americans who suffer from arthritis, bursitis, tendinitis and a formidable number of other maladies. In the process, it has rapidly become one of the hottest black-market drugs since marijuana. But getting high is about the only thing DMSO isn't used for.

Adherents claim it has cured headaches and toothaches, fought off infections, cleared up frostbite, varicose veins and acne. Its more fanatic boosters claim it can cure baldness, mental retardation, psychoses and cancer. The Food and Drug Administration, which has known about people using DMSO for nearly 20 years, outlawed it in 1965 when it was found to cause eye damage in laboratory animals. The agency's voluminous statements on the subject since then boil down to this: There are no tests sufficient to prove the claims of its supporters. Therefore, pending FDA approval, the National Arthritis Foundation reserves judgment on DMSO and cautions about "sensational testimonials, unscrupulous promoters and unsafe products." They warn that some users are buying forms of DMSO that are too strong for use on humans and can cause rashes and burns. The foundation's biggest worry is that patients who opt for DMSO will neglect proven forms of treatment.

But surgeon Stanley Jacob, 57, sometimes called "the Father of DMSO," has treated tens of thousands of patients at his office at the University of Oregon Health Sciences Center in Portland—and now sees more than 200 a week. Some are victims of paralysis who come for injections of DMSO in the spine. "None of those patients has run a four-minute mile," he reported, "but some have shown improvement." He claims results with a wide range of muscular conditions, burns and spinal cord injuries. "DMSO has the largest potential number of uses ever documented for a single chemical," Jacob has said. "There's nothing like it."

Jacob's practice is the tip of an iceberg. Millions of Americans are using DMSO on their own, and a far-flung network of retailers is springing up to serve them. Carpet stores, ice cream parlors, even dry cleaners have turned to selling DMSO as a sideline. Except in Louisiana, Oregon and Florida, where legislators have legalized medical uses of the drug, its new promoters skirt the issue adeptly. In San Francisco a sign behind the counter in one surplus store warns clerks, "We are not allowed to say DMSO cures arthritis. Say it is a solvent."

Despite such constraints, business is booming. Dallas-Fort Worth dealers are selling DMSO from tailgates at ad hoc roadside stands. In Florida some two dozen establishments are offering vacation package deals for DMSO treatments, including room and board. Marty Friedman, who operates a hobby store in Thousand Oaks, Calif., first ordered a batch of DMSO for a customer last March. A few weeks later Dr. Jacob appeared on 60 Minutes with some of his patients. Their testimony impressed even the usually skeptical Mike Wallace (and reportedly prompted CBS chieftain Bill Paley to see Jacob). Jacob's hospital had to hire a dozen extra operators to handle the calls—and DMSO suppliers like Marty were deluged overnight with business. When Friedman ran out of bottles, he recalls, patrons brought their own mayonnaise jars. When he ran out of DMSO, they scalped the stuff outside his store. Solvent Sales Inc. of Seattle takes thousands of orders a week by phone. The bottles come with an offer to customers to become local distributors of the product, and company president Billy Williams says they're signing up. "I know what we're selling it for," he says coyly. "We're selling it for a profit."

By far the biggest U.S. producer is Crown Zellerbach Corp., a giant paper company headquartered in San Francisco. Crown reportedly produces a million gallons of the stuff every year. Less than 10 percent is earmarked for medicinal use, and a spokesman explains that the company cannot be responsible for how the substance is used after it leaves the plant.

For all the money being made by the producers and middlemen of DMSO, the question of how effective it is remains unanswered more than 100 years after its discovery. First isolated by a Russian scientist in 1866, DMSO was only a laboratory curiosity until a Crown Zellerbach chemist, Robert Herschler, began experimenting with it in the early '60s. Jacob got interested a year later because DMSO's ability to act as a human antifreeze—preventing cells from rupturing when frozen—had applications in the kidney transplant research he was doing at the time. By the time of the FDA ban in 1965 some 100,000 Americans had tried the stuff—and 1,500 doctors had tested it. Americans continued using DMSO in spite of the ban. Some bought it in other countries, others obtained it from sympathetic veterinarians, who have used it legally for years. Some physicians openly flouted the law. Richard Bachrach, a New York osteopath, used to supply it to his patients. "It's so widespread," he claims, "there's not a professional sports team or dance company that doesn't use it."

Efforts to get FDA approval, however, have been unavailing. Though the research literature on DMSO is already considerable, many of the favorable studies have been criticized and their results discounted. The FDA points out that because of the drug's strong odor it is impossible to administer conclusive "double-blind" studies—tests in which the researchers do not know which subjects have been given DMSO and which have been given a placebo. The FDA does not test substances itself, moreover; it must rely on others—and others besides Jacob have been hard to find. Crown Zellerbach says it favors FDA approval for DMSO, and it invites "some major pharmaceutical company to follow the FDA procedures to achieve that goal." But the nation's drug companies are understandably reluctant to undertake costly testing that would benefit only Crown, which holds patents on the use of DMSO as a painkiller. Furthermore, DMSO would be a cheap substitute for some of their most lucrative products. Except among consumers, there seems little economic incentive to bring DMSO up from underground. The going rate—$20 and up for an eight-ounce bottle—suggests that between the time it leaves Crown and the time it reaches the consumer it is generating a 1,000 percent profit.

The FDA says it is still waiting for adequate tests, but critics of the agency claim it will never be legalized because of political pressure from drug companies. Says Bachrach: "It's disgraceful. Clearly, there's been ample time for study." The co-discoverer, Herschler, now no longer with Crown, agrees: "The FDA is far more interested in rules and regulations than health and welfare. I hold them responsible for every death and mutilation that might not have happened if DMSO were freely available." Last year Jacob tried taking his case to the public. ("Americans," he declared, "are getting shafted.") But then he began refusing interviews, fearing that his high profile has antagonized the FDA.

There is some sign that legalization may be coming. A bill to require the National Institutes of Health to test DMSO died in the current lame-duck Congress. But Oregon Sen. Robert Packwood recently contacted FDA Director Jere Goyen on the problem and promises to keep pushing. "I am tired of the FDA dragging its feet," he says. "I told him he ought to make a decision on the merits of the drug, instead of harassing Jacob."

The 18-year struggle with the FDA and the scientific community over DMSO has taken its toll on Dr. Jacob. The father of five children, now 3½ to 29 years old, he attributes the failure of his three marriages in part to his "obsession" with the drug. He has been taking DMSO himself ever since 1963—"not for any medical problem but because if any side effects are going to develop, it's better that they raise their ugly head in my body than anyone else's." His interest in the drug's approval is, he says, purely altruistic: He will not get rich, because royalties on the patents he shares with Crown go to the university health center. Whether or not DMSO is legalized, Dr. Jacob expects to devote the rest of his working life to it. "I might spend a little more time with family," he says, "but my research interests wouldn't change. I couldn't begin to scratch the surface of DMSO's uses in the years remaining to me."

 

 

For some Cannabis Oil and DMSO pain relief cream recipes:  http://forum.flyings...or-pain/?p=1710







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